Deleting this collection CANNOT be undone. A cup of ewe eje extract in the morning will provide you with energy needed to pull through the days activities. In phase two, three rats were separated into 3 groups of one rat per group. Inter J Biochem Cell Bio. Joseph, H., Gleye, J., Moulis, C., Mensah, L. J., Roussakis, C., and Gratas, C. Justicidin B, a cytotoxic principle from Justicia pectoralis. Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system. Keep the soil moist, but not waterlogged. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The compound responsible for this activity is lignan. Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. The acute toxicity test also proved that justicia carnea leaves are safe for consumption. View abstract. Free radicals and antioxidants in normal physiological functions and human disease. It also increases good cholesterol levels. At the end of the 14th day of administration, the rats were allowed to fast overnight and sacrificed the following morning by anesthetizing each rat in a closed chamber containing drops of chloroform. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Too much sun can scorch the leaves, and too little will result in fewer flowers. View abstract. Too much fertilizer is damaging for your plant. While not necessary, prune the justicia (plant) freely to maintain the desired shape and size. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. The Hematological system and antioxidant status of rats following 14days of sub-acute exposure tolerated the ethanol extract of J. carnea leaf. As for light exposure, keep the plant away from the full sun. BMC Complem Altern Med. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). The antidiabetic effect of justicia is through the inhibition of-amylase and -glucosidase, the carbohydrate metabolizing enzymes, and also through its hypolipidemic potential. The renal effects of blood glucose-lowering plant-derived extracts in diabetes mellitus-an overview. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. The presence of blood boosting nutrients such as iron, copper, zinc and vitamin C can help prevent iron-deficiency anaemia and other anemic conditions. The ability of glutathione to regenerate these dietary antioxidants has been linked to the redox state of glutathione disulphide-glutathione couple (GSSG/GSH) ratio [31]. Ewe eje or Ewe ajeri is known by the Igbo tribe as Ogwu obara. Clin Phytosci 7, 2 (2021). Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. Rats were further observed for extended hours of 48h to see if mortality would occur. Whether added to garden beds or pots, the justicia (plant) adds a colorful tropical touch and are easy to grow. There should be further studies on the antidepressant activity of justicia carnea leaves. Fresh leaves of Justicia carnea were collected from Okitipupa area Ondo State. J Ethnopharmacol. Article Faiza R, Waqas KK, Adeel M, Muhammad G. Detection of bioactive fractions of Justicia adhatoda leaves. Tietz NW. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. There may be some problems if the air is too dry in winter. Turn off the heat and then soak the leaves into the pot. The plant has various other common names including: Back in the day, the Justicia flower was boiled and used to solve anemia problems. Another strong benefits of justicia carnea leaves is in lipid profile. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. 2003;66:1499503. This claim have not been verified. The reference cuvette contained 2.95ml buffer, 0.03ml of substrate (epinephrine) and 0.02ml of water. Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. Luckily, the unique flowers of Jacobinia carnea and its foliage are free from major pest and disease concerns. 2007;39(1):4484. Superoxide dismutase (SOD) activities were elevated across all doses in the liver with significant (p<0.05) difference only observed in the highest dose (1200mg/kg) while kidney showed no significant difference compared to the control. Oyenihi OR, Brooks NL, Oguntibeju OO. The principle is based on the formation of coloured complex when protein peptide interacts with cupric ions in an alkaline medium. Despite the use of Justicia carnea and other reported scientific studies, there are no reports on its effects on the major organs of the body. It is obvious that Justicia carnea has potential antianemic, antioxidant, antidiabetic, hepatoprotective, and immune-boosting properties. degree in Biochemistry from Olabisi Onabanjo University, Ago-iwoye, and University of Ibadan, Ibadan, Nigeria respectively. The weight of liver and kidney of rats were measured immediately after excising the organs and is presented in Table2. In this report, MCV, MCH and MCHC in treated group were not altered compared to the control. How Justicia Betonica is effective for various diseases is listed in repertory format. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. Phytother Res 2011;25(3):444-450. 1999;9:18. To create additional collections, you must be a paid member of our site. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. Phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis indicated presence of . Control treated group showed normal micromorphological sections. CAS Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Once the roots have established, adjust watering to three to five days apart. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. WebMD does not provide medical advice, diagnosis or treatment. J Nat Prod 1988;51(4):804-805. Make sure to follow the package instructions carefully. Why urban citizens in developing countries use traditional medicines: the case of suriname. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2017;16(2):21730 https://doi.org/10.17306/J.AFS.2017.0492. W Afr J Biol Sci. The mixture was incubated at 28C for 30min and the absorbance read at 550nm against the reagent blank. In the winter, temperatures between 60 64 degrees Fahrenheit (15 18 C) are ideal. Sedlak J, Lindsay RH. Cookies, This site is protected by reCAPTCHA and the Google, Justicia scheidweileri (Purple Shrimp Plant), Justicia americana (American Water-Willow), Want Garden Inspiration? Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. International Journal of Phytomedicine and Phytotherapy, Clinical Phytoscience It results from one or more of the following events: loss of red blood cells (RBCs), reduction in the production of RBCs, increased destruction of RBCs, and shorter life span of RBCs (McEvoy, 2013). Justicia Carnea is a flowering plant that may be found in our neighborhood. The results of this study suggests that ethanol extract of J. carnea leaf is relatively safe, could be beneficial in alleviating hematology related abnormalities without causing adverse effects on endogenous antioxidant system. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. Acta Sci Pol Technol Aliment. The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). Another plant with this benefit is fertility tree. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. [4].Inflammationinjuries, in an attempt to heal is presented by five cardinal signs of heat (calor), redness (rubor), swelling (tumor), pain (dolor) and loss of function5.Studieshave demonstrated inflammation as being caused by what are the pros and cons of testosterone replacement therapy? Total protein concentration in tissue homogenates were determined using biuret method Tietz [16]. The Pros and Cons of Creatine You Should Know. Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. Paes-Leme AA, Motta ES, De Mattos JCP. At this time there is not enough scientific information to determine an appropriate range of doses for Justicia pectoralis. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. Arch Toxicol. It is not. Recently, it has also been reported that the species possess cardioprotective properties, antioxidant and are generally rich in vitamins and minerals [10,11,12]. de Smet, P. A. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). PubMed All rights reserved. Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. Radhika J, Sathya S, Jothi G, Japasheba JL. Acute toxicity was determined in two phases using Lorke method. The plant is hardy to USDA Hardiness Zones 8b through 11. Wash the Justicia carnea leaves thoroughly to eliminate all forms of insects and dust. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Backfill the soil gently, filling the empty space around the root ball and then press it down with your hands. Different drugs are used but many depend mainly on plants and herbal products for its treatment. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). Mr. T.S. long (20 cm), densely packed with pink to crimson tubular flowers. Uses, Benefits, Cures, Side Effects, Nutrients in Justicia Betonica. Ewe eje is a rich source of phytochemicals, minerals and vitamins. J Ethnopharmacol 1984;12(1):93-111. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. The lush foliage and distinctive flowers make Brazilian Plume a natural for a . Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in. The leaves were able to greatly lower the total cholesterol, LDL-cholesterol, and triglyceride levels, but increased the serum level of high density lipoprotein (HDL) cholesterol. 1. Tips on how to get rid of leaf eating caterpillar. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. CAS 16. 2005 - 2023 WebMD LLC, an Internet Brands company. Google Scholar. Aim. J Nat Prod 1988;51(3):599-600. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. Rich on haematological and biochemical parameters in healthy Wistar rats. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. 2. This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. The gradual decrease in the weight of organs following short-term exposure of J. carnea leaf ethanol extract may be attributed to adaptive response of the organs arising from daily dosage of the extract or its metabolites within their body. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). Only plants will be removed from the collection. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. Group 2, 3, 4, 5, 6 were respectively administered orally with 50, 100, 500, 800 and 1200mg/kg body weight of JCEE once daily for 14days using an oral gavage. This special leaf can be found around us- in our neighborhood. Note: A=change in absorbance, TV=total volume, SV=sample volume, =molar extinction=4020M1cm1, TP=total protein. Add organic matter or compost in the soil and place the plant. 3 . Leaf extract in isoproterenol induced myocardial infarction in albino rats. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Keep in mind that natural products are not always necessarily safe and dosages can be important. To use the website as intended please Lipid peroxidation was determined by measuring the formation of thiobarbituric acid reactive substances (TBARS) according to the method described by Buege and Aust [20]. Yes my readers. These minerals help in boosting blood production, which is why the plant is called ogwu obara (blood medicine) among the Igbo people of Southern Nigeria. 2008; 10:2. Justicia carnea needs bright, indirect light to thrive. The weight of organs (liver and kidney) reduced steadily in a concentration dependent manner. J Ethnopharmacol 2000;70(2):151-159. You can add the leaves and water altogether in a pot and allow to boil till the water turns red. It is a creeping, perennial plant and grows up to 2 meters tall. Where, A=absorbance, TV=total volume, SV=sample volume, =extinction coefficient, TP=total protein. So lets go through this together. https://doi.org/10.35841/biomedicalresearch.30-18-666. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. Cardioprotective role of Justicia traquebareinsis Linn. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. 1978;52:30210. Philadelphia: WB. van Andel T., Carvalheiro LG. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. 2008;108(9):14807. In traditional medicine, justicia carnea is used in treating hepatitis. J. Appl. Dyslipidemia is one of the risk factors of cardiovascular diseases. However, the mechanism by which phytochemicals act as prooxidants in-vivo is still under investigation [25]. Nutritional Composition of Ewe eje (Justicia carnea leaf). You can add milk or honey for taste before drinking. The description of these plants has been written based on numerous outside resources. This leaf replenishes your blood supply immediately. Over time, they cause atherosclerosis and myocardia infarction. The major use of Justicia carnea leaves is to improve blood production. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. The kidney of rats treated with doses of J. carnea ethanol extract revealed dose dependent degree of renal injury (Fig. Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. View abstract. 2002;82:197205. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. The blood stimulating effects could be due to the presence of dietary bioactive constituents that stimulate activities of haematopoietic cells and stabilization of blood in circulation [21]. The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. READ ALSO: How long does it take for Aju mbaise to work. The absorbance was read at 412nm against the reagent blank. He is a research assistant in the Biochemistry Unit of the same Department. 2012; 22(1):220238; https://doi.org/10.1590/S0102-695X2011005000196. International Journal of Biochemistry Research & Review. Biochemistry Unit, Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Nigeria, Emmanuel Sina Akintimehin,Kayode Olayele Karigidi,Tope Samuel Omogunwa&Foluso Olutope Adetuyi, You can also search for this author in The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. Mr. K.O. All analyzed dataset to support the conclusions of this article is included as tables in the uploaded supplementary files. Despite the avalanche use of medicinal plant, preliminary toxicity studies remain essential tools to ensure safe consumption and prevent unexpected toxicity that could arise from long term exposure. In this study, the aqueous leaf extract of Justicia carnea was used. Article ID 687197, 2013; p. 13. https://doi.org/10.1155/2013/687197. Microsomal lipid peroxidation. Treatments of all experimental animals were performed following Principle of Laboratory Animal Care manual guidebook of National Institute of Health as approved by the Research Ethics Committee of Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State. In recent time, copious attention has been focused on the use of medicinal plants in the management and treatment of ailments such as anemia, diabetes and malaria. (2017). https://doi.org/10.13040/IJPSR.0975-8232. Part shade is the ideal growing condition for Brazilian plumes. Google Scholar. Two of the most important soil considerations include fertility and drainage. There are several scientific studies which show that the methanolic leaf extract of Justicia carnea protects the liver from toxic effect of carbon tetrachloride harmful effect on the live integrity and functions. Further, 0.5ml of supernatant was treated with 0.5ml of Ellmans reagent (containing 19.8mg of 5,5 dithiobis - (2-nitrobenzoic acid) (DTNB) in 100ml of 0.1% sodium nitrate) and 3.0ml of phosphate buffer (0.2M, pH8.0). Ewe eje is safe and healthy for consumption. While vitamin A maintains good vision, vitamin B are good for cellular functions such as metabolisms and energy production, and improve brain functioning. Also, remove old flowers to keep the plant healthy. Google Scholar. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. hindawi publishing corporation evidence-based complementary and alternative medicine. We'll respect your privacy and unsubscribe at any time. The lush foliage and distinctive flowers make Brazilian Plume a natural for a tropical garden. Contamination of medicinal plant could be as a result of contaminants (such as heavy metals, aflatoxin and pathogenic microbes) from soil and manner of herbal preparations [4]. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. The significant increase in MDA level at 1200mg/kg might be due to the presence of active secondary metabolites in the extracts that could have acted as prooxidant. Tissues were processed automatically using automatic tissue processor (Leica TP 1020) and allowed to pass through varying percentage of alcohol and absolute alcohol for the purpose of dehydration following dewaxing in Xylene for 15mins. SOD is involved in the dismutation of the highly reactive superoxide anion to molecular oxygen (O2) and to less reactive hydrogen peroxides (H2O2) species, whereas CAT removes hydrogen peroxide (H2O2) and toxic hydroxyl radical into water molecule [35]. B-vitamins are good sources of energy. Mr. E.S. Fertility leaves: Benefits and side effects, Guava Leaf Tea: Health Benefits of Guava Leaves, Coriander seeds: 18 benefits Coriandrum sativum fruits and seeds, Rapini: Nutritional facts, benefits, side effects and care. Tropical habitats mean constant moisture. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. Catalase activity (U/ml) was measured following the method of Sinha [17]. This requires more attention to properly document the various health benefits of justicia carnea. By using this website, you agree to our The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. The plant possess several bioactive compounds like polyphenols, which act as antioxidants or anti-inflammatory compounds. Significant (P<0.05) decrease observed in liver total protein of rat administered with 1200mg/kg of extract could be due to intrinsic factors in-vivo that might not necessarily indicate adverse reaction of the extracts. The plants cannot be propagated with seeds. Ewe eje or ewe ajeri is prepared differently by different folks. View abstract. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations.
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